Anti-phospholipase A2 receptor antibody in membranous nephropathy; an Indian experience

Anti-phospholipase A2 receptor antibody in membranous nephropathy; an Indian experience

Implication for health policy/practice/research/medical education: In an observational study,a group of patients with membranous nephropathy showed correlation of anti-PLA2R antibodies with disease activity and presence of primary MN. Please cite this paper as: Yachha M, Sharma RK, Mehrotra S, Prasad N, Gupta A, Kaul A, Bhadauria DS. Anti-phospholipase A2 receptor antibody in membranous nephrop...

Anti-phospholipase A2 receptor antibody in membranous nephropathy.

The M-type phospholipase A2 receptor (PLA2R) is a target autoantigen in adult idiopathic membranous nephropathy (MN), but the prevalence of autoantibodies against PLA2R is unknown among Chinese patients with MN. Here, we measured anti-PLA2R antibody in the serum of 60 patients with idiopathic MN, 20 with lupus-associated MN, 16 with hepatitis B (HBV)-associated MN, and 10 with tumor-associated ...

current concepts on anti-phospholipase a2 receptor antibody in idiopathic membranous nephropathy.

letter to the editor

Anti-phospholipase A2 Receptor Antibody and Immunosuppression in Membranous Nephropathy: More Evidence for Pathogenicity of Anti-phospholipase A2 Receptor Autoantibodies.

In the 6 years since the discovery of anti-phospholipase A2 receptor (anti-PLA2R) antibodies in the majority of patients with primary membranous nephropathy (MN),1 our understanding of the role of anti-PLA2R in clinical disease has evolved rapidly. The initial small retrospective clinical studies indicated that anti-PLA2R levels could be modulated by immunosuppression.1,2 Levels decreased in ad...

Idiopathic membranous nephropathy and anti-phospholipase A2 receptor antibodies.